About Retrinal+ by Avene :
View Resource Articles on Retrinal by Avene
 New Formulations!
Helps prevent and reduce the visible signs of aging -- with little to no irritation!
Formulated with 2 exclusive ingredients: Retinaldehyde (a.k.a. retinal), the immediate precursor to retinoic acid and one of the most effective forms of Vitamin A, and patented antioxidant Pre-Tocopheryl, a photostable form of Vitamin E, Retrinal+ 0.05% and 0.1% Cream has been clinically proven to help prevent and reduce the visible signs of aging with little to no irritation. Retrinal+ is available in two concentrations -- 0.05% and 0.1% -- to address individual skin-aging concerns.
 Delaying the visible signs of skin aging has become a priority for women and men of all ages beginning as early as their mid twenties. Prevention is key to maintaining skin health and youthfulness. As skin matures, the skin rejuvenation protocol becomes more of a corrective and restorative measure. 
- Retrinal+ 0.05% Cream – 0.05% Retinaldehyde and a patented antioxidant (Vitamin E): Nightly skin rejuvenation
- Retrinal+ 0.1% Cream – 0.1% Retinaldehyde and a patented antioxidant (Vitamin E): Intensive skin rejuvenation
- Retrinal H.A.F. Firming Gel – 0.05% Retinaldehyde + Hyaluronic Acid Fragments (H.A.F.) : Target at deep lines and wrinkles. Applied nightly in conjunction with Rétrinal Cream
In just one step, the body can convert retinaldehyde to retinoic acid. Treating the skin with retinaldehyde can produce therapeutic levels of retinoic acid while reducing the risk of side effects associated with retinoid excess.
A French study by Dr Boisnic and co-workers (published in the journal Dermatology in 1999) looked at the ability of retinaldehyde to reverse skin damage induced by UVA radiation. The researchers concluded that retinaldehyde exhibited "many of the properties of tretinoin [trans-retinoic acid] in its biological and beneficial effects on photoaging" and in particular improved dermal connective tissue by boosting "repair of elastic fibers and reversing collagen alteration induced by UVA exposure".
In addition to skin rejuvenation, there is another application where retinaldehyde may prove comparable or even superior to retinoids -- treatment of acne. Retinoids, such as retinoic acid (tretinoin, Retin-A), have been one of the established acne treatments for decades. Considering that retinaldehyde is converted to retinoic acid in the body it could conceivably have the same effect on acne as directly acting retinoids. Since retinaldehyde is less irritating than retinoids, retinaldehyde may be easier to combine with other potentially irritating acne treatments, such as alpha-hydroxy acids, beta-hydroxy acids or benzoyl peroxide. There is also evidence that retinaldehyde possesses some antimicrobial activity against P. acnes, the bacteria involved in the development of acne.
Topical skincare products containing retinaldehyde, such as Avene Retrinal+ Cream 0.05% and Avene Retrinal+ Cream 0.1%, are available without a prescription. While these skincare products are less irritating than tretinoin, they can still cause skin irritation and/or excessive dryness in sensitive individuals.
It is often recommended that one start with a lower concentration (Avene Retrinal+ Cream 0.05%) and/or apply less frequently (e.g. every other day) and then gradually increase the concentration/frequency to the desired level.
Sunscreen Recommendation: Therapy with Retrinal+ Cream by Avene may make your skin more susceptible to sunburn and other adverse effects of the sun. Apply a sunscreen every morning after cleansing. Also, try to avoid excessive exposure to wind or cold.
Pregnancy and Nursing Advisory: In an effort to avoid injury to the developing baby, most skin care topicals have not been clinically tested on pregnant or nursing women; therefore, we advise that they not be used. Products containing hydroquinoine or products containing retinoids should NOT be used when pregnant or nursing. You should also discontinue the use of skin care products containing these ingredients for at least one month before contemplating pregnancy. If in doubt, please refer to the product insert for further information and consult with your physician.
Retrinal Cream by Avene can be added to any skin care regime for improved results. Please call our office at 1-877-415-0600, Monday through Friday, 8:30 a.m. to 7:30 p.m. EST for more details about Retrinal Cream by Avenue and its use.
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